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KMID : 0363320070280030502
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Journal of Korean Oriental Internal Medicine
2007 Volume.28 No. 3 p.502 ~ p.509
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Effects of Folium Perillae on Cerebral Ischemia in Rats
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Kim Hyung-Woo
Kim Bu-Yeo
Cho Soo-Jin
Jung Hyun-Woo
Cho Su-In
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Abstract
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Objectives : Folium perillae (FP) can relieve superficial pathogenic factors to dissipate cold and promote the circulation of qi and regulate the function of the stomach and is often used for interior qi-stagnation. We hypothesized that FP could rescue cerebral ischemia in rats.
Methods : The present study was carried out to investigate the effects of FP on cerebral ischemia in terms of regional cerebral blood flow (rCBF) and mean arterial blood pressure (MABP) in rats. Finally, lactate dehydrogenase (LDH) release was investigated, too.
Results : In this study, treatment with FP elevated rCBF and MABP levels in dose-dependent manner. Pre-treatment with indomethacin, an inhibitor of cyclooxygenase, inhibited rCBF increase induced by FP effectively. However, FP did not affect stability during cerebral reperfusion. Finally, FP significantly inhibited LD H activity in vitro.
Conclusions : These results suggest that FP is useful to treat patient with diseases related to cerebral ischemia, because FP can increase rCBF and MABP.
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KEYWORD
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Folium Perillae, cerebral ischemia, regional cerebral blood flow, lactate dehydrogenase
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